產(chǎn)品描述

塔望科技開發(fā)的小動物頭外置體積描記系統(tǒng)（Head-Out Plethysmography），采用特殊設(shè)計(jì)，使小動物的頸部與身體隔開，口鼻暴露在外面，實(shí)時(shí)測定容納身體的腔室內(nèi)氣體容積與壓力的變化。Glaab等對哮喘小鼠使用mACh激發(fā)后，取呼氣中段流量(EF50 )下降55％時(shí)的mACh量( EF50)為指標(biāo)來表示支氣管反應(yīng)的敏感性，研究證明，EF50和RL及CL有較好的相關(guān)性，可較好地反映呼吸系統(tǒng)的機(jī)械動力學(xué)改變。

產(chǎn)品特點(diǎn)

小動物頭外置體積描記系統(tǒng)采用頭外置式體積描記系統(tǒng)測量過程中，動物保持清醒狀態(tài)，不需要麻醉，避免了創(chuàng)傷性氣管切開術(shù)及麻醉的影響，使實(shí)驗(yàn)過程簡便快捷，并適合長期跟蹤研究。

另外系統(tǒng)可擴(kuò)展連接霧化給藥器，對動物進(jìn)行霧化給藥，建立咳嗽、哮喘等呼吸道疾病模型，系統(tǒng)可檢測和記錄激發(fā)過程中呼吸常規(guī)指標(biāo)和氣道高反應(yīng)的變化，用以評價(jià)支氣管收縮情況。

• 不需要做手術(shù)，操作簡單。

• 動物處于清醒狀態(tài)，結(jié)果不受麻醉和手術(shù)影響。

• 可以實(shí)現(xiàn)在同一只動物上做長期跟蹤實(shí)驗(yàn)。

• 配備氣溶膠霧化模塊 。（可根據(jù)實(shí)驗(yàn)要求選配）

• 可聯(lián)合同步測量其它信號，如體溫、血壓、心電信號等。

小動物頭外置體積描記系統(tǒng)可連接口鼻暴露系統(tǒng)，實(shí)時(shí)在線監(jiān)測動物肺功能指標(biāo)的變化

檢測參數(shù)

小動物頭外置體積描記系統(tǒng)

Ti：吸氣時(shí)間（s）

Te：呼氣時(shí)間（s）

PIF：最大吸氣流速（ml/s）

PEF：最大呼氣流速（ml/s）

Volbal：吸氣時(shí)間/呼氣時(shí)間

F：呼吸頻率（次/min）

Vt：潮氣量（ml）

Mv：分鐘通氣量（ml）

AV：累積體積（ml）

EF50：呼出50%氣量時(shí)對應(yīng)的呼氣流速（ml/s）

EIP：吸氣末暫停時(shí)間

EEP：呼氣末暫停時(shí)間

TR：松弛時(shí)間

PenH：增強(qiáng)呼氣間歇（enhanced pause）

Rpef：相對時(shí)間

小動物頭外置體積描記系統(tǒng)應(yīng)用領(lǐng)域

哮喘Asthma

肺纖維化Lung Fibrosis

慢性阻塞性肺病COPD

急性呼吸系統(tǒng)疾病Acute Respiratory Disorders

模型開發(fā)Model Development

安全評估 Safety Assessment

毒理學(xué)Toxicology

小動物頭外置體積描記系統(tǒng)型號選擇

小動物頭外置體積描記系統(tǒng)用戶名單

小動物頭外置體積描記系統(tǒng)相關(guān)文獻(xiàn)

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